Improvement of Lean body mass:

Most obese and overweight people have inadequate levels of the cyclic AMP enzyme. This enzyme is important in triggering biochemical processes that cause the breakdown of fats to release energy. Since Coleus Forskohlii is a cyclic AMP agonist, belly fat is burned up and energy produced making the person more energetic. There is a faster breakdown of fats because of thermogenesis, therefore higher internal temperature that boosts metabolism so that calories burn faster. This makes it necessary to keep hydrated while taking this supplement. Generally, there is loss of body fat and a boost in lean body mass (when accompanied by a low-calorie diet and exercise).

Heart and Thyroid:

Forskolin stimulates and activates the enzyme adenylate cyclase in the heart and smooth muscle. This causes increased production of cyclic AMP (cAMP), which causes calcium channels to open and intracellular calcium concentrations to increase, resulting in increased contractility of heart muscle and relaxation of smooth muscle. Other organs, like the thyroid gland, may also benefit from the activation of cAMP.

Allergic Conditions:

Allergic conditions like asthma, hay fever and eczema are marked by low cAMP and high platelet activation factory (PAF) levels, therefore Coleus is specifically indicated for both. The increase in cAMP results in reduced mast cell histamine release.